https://phlox.or.id/index.php/sjn <p><strong>Sriwijaya Journal of Neurology (SJN) </strong>is an international, peer-review, and open access journal dedicated to neurology. <strong>SJN</strong> publishes twice a year. The journal publishes all type of original articles, case reports, review articles, narrative review, meta-analysis, systematic review, mini-reviews and book review. <strong>SJN</strong>&nbsp;is an official journal of <a href="https://institute.phlox.or.id/" target="_blank" rel="noopener">Phlox Institute: Indonesian Medical Research Organization</a>. SJN has e-ISSN <a href="https://issn.brin.go.id/terbit/detail/20230426141725721" target="_blank" rel="noopener">2987-1425</a>.</p> <p><a href="https://issn.brin.go.id/terbit/detail/20230426141725721" target="_blank" rel="noopener"><img style="display: block; margin-left: auto; margin-right: auto;" src="/public/site/images/taryudi_sjn/BARCODE_2987142500.png"></a></p> Phlox Institute: Indonesian Medical Research Organization en-US Sriwijaya Journal of Neurology 2987-1425 <p><strong>Sriwijaya Journal of Neurology (SJN) </strong>allow the author(s) to hold the copyright without restrictions and&nbsp; allow the author(s) to retain publishing rights without restrictions, also the owner of the commercial rights to the article&nbsp; is&nbsp; the author.</p> https://phlox.or.id/index.php/sjn/article/view/170 <p><strong>Introduction:</strong> Burning mouth syndrome (BMS) is a chronic pain condition characterized by a burning sensation in the oral cavity without any identifiable clinical or laboratory findings. While the etiology of BMS remains unclear, central sensitization and neuropathic pain mechanisms are increasingly recognized as potential contributors. This study aimed to investigate the role of central sensitization and neuropathic pain in BMS patients in Bandung, Indonesia.</p> <p><strong>Methods:</strong> This cross-sectional study involved 40 participants diagnosed with BMS according to the International Association for the Study of Pain (IASP) criteria and 40 healthy controls. All participants underwent comprehensive assessments, including: (1) clinical oral examination, (2) quantitative sensory testing (QST) to assess thermal and mechanical sensitivity, (3) questionnaires to evaluate pain intensity, quality of life, anxiety, and depression, and (4) measurement of salivary cortisol levels as a marker of stress.</p> <p><strong>Results:</strong> BMS patients exhibited significantly higher thermal and mechanical sensitivity compared to healthy controls (p&lt;0.001). They also reported significantly higher pain intensity, poorer quality of life, and increased levels of anxiety and depression (p&lt;0.001). Salivary cortisol levels were significantly elevated in the BMS group (p&lt;0.05). Correlation analysis revealed significant associations between pain intensity and QST parameters, anxiety, depression, and salivary cortisol levels.</p> <p><strong>Conclusion:</strong> The findings of this study suggest that central sensitization and neuropathic pain mechanisms play a significant role in the pathophysiology of BMS in Bandung, Indonesia. These findings highlight the need for a multidisciplinary approach to BMS management, incorporating strategies to address both peripheral and central factors contributing to pain.</p> Muhammad Ashraf Syaifudin Syaifudin Andhika Kurnianta Kusuma Duru Carissa Neuer Eduardo Michael Perez Copyright (c) 2025-01-24 2025-01-24 2 2 159 171 10.59345/sjn.v2i2.170 https://phlox.or.id/index.php/sjn/article/view/171 <p><strong>Introduction:</strong> Parkinson's disease (PD) is a neurodegenerative disorder that affects motor and non-motor functions, including oral health. This longitudinal study aimed to investigate the oral health status of PD patients in Semarang, Indonesia, and its association with disease severity over time.</p> <p><strong>Methods:</strong> A cohort of 100 PD patients diagnosed according to the UK Parkinson's Disease Society Brain Bank criteria were recruited from the Neurology Clinic of Private Hospital, Semarang. Oral health assessments, including Decayed, Missing, and Filled Teeth (DMFT) index, periodontal status, and oral hygiene habits, were conducted at baseline and annually for three years. Disease severity was assessed using the Hoehn and Yahr (H&amp;Y) scale and the Unified Parkinson's Disease Rating Scale (UPDRS). Data were analyzed using descriptive statistics, correlation analysis, and regression models.</p> <p><strong>Results:</strong> The majority of PD patients exhibited poor oral hygiene and a high prevalence of dental caries and periodontal disease. DMFT scores and periodontal indices worsened significantly over the three-year follow-up period. Disease severity, as measured by H&amp;Y stage and UPDRS scores, was significantly correlated with poorer oral health status. Regression analysis revealed that higher UPDRS scores at baseline predicted a more rapid decline in oral health over time.</p> <p><strong>Conclusion:</strong> PD patients in Semarang, Indonesia, experience significant oral health challenges that are associated with disease severity and progression. These findings highlight the need for integrated oral healthcare in the management of PD to improve patients' overall quality of life.</p> Husin Sastranagara Syaifudin Syaifudin Tan Kiew Lee Nurul Hanifah Brian Edgar Wicaksana Copyright (c) 2025-01-31 2025-01-31 2 2 172 184 10.59345/sjn.v2i2.171