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Abstract
Introduction: Hirschsprung disease (HSCR) necessitates early diagnosis to prevent complications. Rectal suction biopsy (RSB) offers a less invasive alternative to full-thickness biopsy. This study evaluates RSB's diagnostic accuracy in a Thai pediatric population.
Methods: A retrospective review analyzed children suspected of HSCR who underwent RSB at a tertiary Thai hospital (2018-2024). RSB findings were compared to the gold standard (full-thickness biopsy or intraoperative findings). Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated.
Results: 120 children (median age 2 months, range 1 day - 12 years) were included. RSB yielded 45 positive and 75 negative results. Gold standard confirmed 40 true positives, 5 false positives, 70 true negatives, and 5 false negatives. RSB's sensitivity was 88.9%, specificity 93.3%, PPV 88.9%, NPV 93.3%, and accuracy 91.7%.
Conclusion: RSB demonstrates high diagnostic accuracy for HSCR in Thai children. It can serve as a valuable initial diagnostic tool, potentially reducing the need for full-thickness biopsies.
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Scientific Journal of Pediatrics (SJPed) allow the author(s) to hold the copyright without restrictions and allow the author(s) to retain publishing rights without restrictions, also the owner of the commercial rights to the article is the author.